Background:

Chemistry and Pharmacy:

• M.Sc.(Chem), Organic Chemistry Specialty, University of Murcia (Spain) in 1978 (1973-78). MSc Thesis and Licenciate Degree.
• Internship: one year (1977-1978) in the laboratory of the Department of Organic Chemistry and Biochemistry, University of Murcia, Murcia, Spain. Subject of Investigation: Glycosides.
• Teacher: one year (1978-79) at "Escuela de Formación Profesional" of Spanish Ministry of Education and Science in Caravaca (Murcia), Spain.
• Fellow of Research: one year (1980-1981) in the laboratory of the Department of Organic Chemistry of the Faculty of Pharmacy, University of Navarra, Pamplona, Spain. Subject of Investigation: New Anti-platelet Agents.
• B.Sc.(Pharm). University School of Pharmacy. University of Navarra, Pamplona (Spain) in 1982 (1980-1982).

• M.D. School of Medicine, University of Valencia (Spain) in 1989 (1983-1989).
• Private Practice in General Medicine: one year (1990) at a private office in a urban area. Valencia, Spain.
• Medical Residency and Intensive Care Medicine Specialty Training: January 1991 to December 1995, after passing the Spanish Nationwide Examination MIR in September 1990. During this period, medical training in the following hospitals: Hospital General of Albacete, Albacete, Spain; Hospital 12 de Octubre, Madrid, Spain; and Addenbrooke´s Hospital, Cambridge, UK. Supported in this period by the following Grants:
 
• Grant from the Ramón Areces Foundation in 1991 for the Seventh Postgraduate Interuniversitary Course of Perinatal Biochemistry: Pathologic Aspects.
• Grant from the Complutense University in 1992 for the Course Cirrhosis, Hyperammonemia and Hepatic Encephalopathy.
• Grant from the Universidad Internacional Menéndez y Pelayo in 1993 for the Course Valvular Replacements for the Heart.
• Grant: "Beca para Estancia en Hospitales Extranjeros" from the Sociedad Española de Medicina Intensiva y Unidades Coronarias , for training as a Registrar in Intensive Care during 1994 in the Addenbrooke's Hospital, Cambridge, UK.

• Specialist in Intensive Care Medicine: Board Certified Diplomate in December 1995.
• European Diploma in Intensive Care (EDIC) in July 1996.
• Ph.D. Diploma in 1997: PhD Student at Universidad Autónoma de Madrid, Spain (1992-96). PhD Thesis "cum laude por unanimidad", presented in January 1997; title:"Evaluation of the Severity Classification Scales in the Critically Ill TISS, APACHE II and III, SAPS II and MPM II". This PhD Thesis was supported by the following institutional grants:
 
• Grant of Research 92177 from the Spanish Health Administration (Consejería de Sanidad de la Junta de Comunidades de Castilla-La Mancha, Spain), in 1992 for the project titled "Evaluation and predictive indices in the critically ill patient".
• Grant of Research 93203 from the Spanish Health Administration (Consejería de Sanidad de la Junta de Comunidades de Castilla-La Mancha, Spain) in 1993 for the project titled "Evaluation of Cost Care Activity in a Intensive Care Unit by using the TISS score".
• Grant of Research 93193 from the Spanish Health Administration (Consejería de Sanidad de la Junta de Comunidades de Castilla-La Mancha, Spain) in 1993 for the project titled "Project of Epidemiological Analysis for Critical Patients in the Hospital General of Albacete".

• FCCS Instructor since 1998.
• FCCP: Fellow of the American College of Chest Physicians since 1999.

• American College of Chest Physicians (ACCP) since 1992.
• Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (SEMICYUC) since 1992.
• Society of Critical Care Medicine (SCCM) since 1993.
• European Society of Intensive Care Medicine (ESICM) since 1993.
• General Medical Council (GMC) since 1994.
• Colegio Oficial de Médicos de Tenerife (COMTF) since 1996.

As Staff Specialist (Consultant) in Critical Care Medicine, serving in the following hospitals:

 
• Hospital "La Inmaculada", Huercal-Overa, Almeria, Spain. Responsible of the Emergency and Critical Care Department of this 250-bed community hospital in a rural area. As the head of this service, great deal of teaching activity with the team of five emergency physicians in a vast majority of emergency and critical care procedures and techniques. Study and experience in the management of poisoned patients, because the intensive agriculture in this area, it is one of the most incidence of pesticide poisonings in the world.
• Hospital "Virgen de la Concha", Zamora, Spain. Intensive Care Attending Specialist in the general ICU of this 500-bed general hospital in a urban area. Implementation of several new protocols and techniques in this ICU.

Since the 1st of July 1996-present, Intensive Care Specialist at Intensive Care Department, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canary Islands, Spain, with clinical, educational an research responsibilities in the 20-bed surgical and medical ICU of this 900-bed university, tertiaty referral center that covers a great rural and urban area.

• Clinical Activities:

The 20-bed general, medical and surgical ICU has about 1,000 admissions/year. The case-mix includes patients with respiratory, cardiac, or renal failure, sepsis and septic shock, pancreatitis and abdominal surgery, postoperative cardiac surgery, poisonings, transplantation, trauma, burns, and neurocritical care. Clinical responsibilities include daily attention to patients, and also 24 hours on call into the hospital each 4-6 days.
 
• Educational Responsibilities:

Since January 2001, Residency and Fellowship Training Program Director:
• Fellowship Program of Lectures in Intensive Care Medicine.
• Professor in the Master Course of Emergency Medicine, Universidad de la Laguna, Tenerife, Spain.

• Research Areas of Interest:

ICU Outcomes and Clinical Toxicology.
 
• Epidemiological Projects for ICU Research and Evaluation (EPICURE).

This includes design and implementation of databases and research projects conceived and arranged for PhD students:
• Databases:
• The EPICURE Database ^TM .
• Mortality Studies:
• Epidemiological Analysis of the post-ICU Occult Mortality in Critically Ill Patients .
• Validation of APACHE II, SAPS II and MPM II as predictors of in-hospital mortality after successful ICU discharge.
• Mortality prediction in head trauma patients by general severity systems.
• Severity of Illness Studies:
• Levels of severity at ICU discharge related those at ICU admission: Criterion for ICU discharge?.
• Toxicological Studies: The ENCANTO Study .

1. Serrano N. Reversión ácida del Metil-D-glucopiranósido. Thesis. University of Murcia, 1978. Murcia, Spain.

2. Soler A, García-Ruiz PA, Serrano N. Oligomerización catalizada por ácidos del Metil-D-glucopiranósido. An Quim 1982; 78: 413-414.

3. Sáez L, Solera J, Serrano N et al. Costochondritis as a late complication of bacteremia caused by Pseudomonas aeruginosa in a non-parenteral-drug-addict patient. Enf Infec Microbiol Clin 1992; 10:568-570.

4. Serrano N, Sánchez M, Cortés JL, García-Sacristán J, Ceres R, Martínez A, Gil R y Fedriani J. Influencia sobre la mortalidad de la estancia hospitalaria previa al ingreso en UCI. Med Intensiva 1994; 18:s120

5. Serrano N, Fedriani J. Evaluación de las predicciones de mortalidad de APACHE II, SAPS II, y MPM II a las 24 y 48 horas de ingreso en UCI. Med Intensiva 1995; 19:s27

6. Serrano N, Fedriani J. Relación entre sistemas de puntuación de gravedad y de esfuerzo terapéutico. Med Intensiva 1995; 19:s28

7. Serrano N, Fedriani J. Nutrición parenteral total en pacientes críticos en ventilación mecánica: Perfil epidemiológico actual. Med Intensiva 1995; 19:s61

8. Serrano N, Fedriani J. Evaluación de índices predictivos en pacientes en ventilación mecánica. Med Intensiva 1995; 19:s76

9. Serrano N, Fedriani J. A comparison of APACHE II, SAPS II, and MPM II-24 and 48 hours models- to predict mortality of ICU patients. Intensive Care Med 1995; 21:s95.

10. Serrano N, Fedriani J. Performance of the relationships between severity of illness and therapeutic effort scoring systems. Intensive Care Med 1995; 21:s95.

11. Serrano N, Fedriani J. Total parenteral nutrition in mechanically ventilated patients: Current epidemiological profile. Intensive Care Med 1995; 21:s42.

12. Serrano N, Córcoles V, Fedriani J. Appraisal of intermittent haemodialysis in critically ill patients before using continuous renal replacement therapy. Blood Purification 1995; 13:395.

13. Serrano N, Cortés JL, Córcoles V, Fedriani J. Hospital ward and emergency room as origin of critically ill patients: A comparative study. Crit Care Med 1996; 27:A41.

14. Serrano N, Cortés JL. An unusual presentation of tracheoesophageal fistula. Intensive Care Med 1996; 22:717-718.

15. Serrano N, Garcia F, Fedriani J. ¿Hepatotoxicidad por flutamida potenciada ante situación hipotensiva?. An Med Intern (Madrid) 1996; 13:552-554.

16. Serrano N. Validación de las escalas de clasificación de gravedad en el paciente crítico TISS, APACHE II y III, SAPS II y MPM II. Doctoral Thesis. Universidad Autónoma de Madrid, 1997. Madrid, Spain.

17. Serrano N, Fedriani J. Fenthion suicide poisoning by subcutaneous injection. Intensive Care Med 1997; 23:129.

18. Serrano N, Mora ML. Another important detail of percutaneous dilatational tracheostomy technique. Chest 1997; 111:1475

19. Serrano N, García de Lorenzo A. Combinación del estado fisiológico agudo del APACHE III y la puntuación de intervención terapéutica TISS en laUnidad de Cuidados Intensivos. Medicina Intensiva 1998; 22:278-279

20. Serrano N, Jiménez JJ, Prieto F, Mora ML. Ether suicide poisoning by intravenous injection. Intensive Care Med 1999; 25:337-338

21. Serrano N, García de Lorenzo A. Aplicación de un sistema de evaluación de gravedad y de intervención terapéutica en el Servicio de Medicina Intensiva. Medicina Intensiva 1999; 23:30-31.

22. Serrano N, Plasencia EJ, Mora ML. Correlación del APACHE II con el SAPS  II: Validación de resultados. Medicina Intensiva 1999; 23:75

23. Sierra B, Serrano N, Larrañaga P, Plasencia EJ, Inza I, Jiménez JJ, De la Rosa JM, Mora ML. Machine Learning Inspired Approaches to Combine Standard Medical Measures at an Intensive Care Unit. In: W. Horn, Y. Shahar, G. Lindberg, S. Andreassen, J. Wyatt (Eds.): Artificial Intelligence in Medicine. Proceedings of the Joint European Conference on Artificial Intelligence in Medicine and Medical Decision Making, AIMDM'99. Springer Verlag, Berlin 1999.

24. Serrano N, Jiménez JJ, Revuelta P, Brouard MT, Mora ML. Oxigenación y compliance durante el prono en el sindrome de distres respiratorio agudo (SDRA). Medicina Intensiva 1999; 23:s

25. Revuelta P, Serrano N, Plasencia E, Jiménez JJ, Málaga J, Brouard MT, Mora ML. Hospital mortality after ICU discharge compared to ICU mortality: A survival analysis. Intensive Care Med 1999; 25:s51.

26. Serrano N, Jiménez JJ, Brouard MT, Málaga J, Mora ML. Acute adrenal insufficiency following cardiac surgery. Crit Care Med 2000; 28:569-570.

27. Serrano N, García de Lorenzo A, Mora ML, Fedriani J. Validación de los Mortality Probability Models II al ingreso (MPM II-0), a las 24 horas (MPM II-24), y a las 48 horas (MPM II-48) comparados con las predicciones de mortalidad hospitalaria de APACHE II y SAPS II realizadas en los días 1 y 2 de estancia en UCI. Medicina Intensiva 2000: 24:49-60.

28. Serrano N, Mora ML. The "breathing-bag" sign in the diagnosis of tracheoesophageal fistula in patients receiving mechanical ventilation. Chest 2000; 117:1217-1218.

29. Serrano N, García de Lorenzo A, Mora ML, Fedriani J. Validación de los Mortality Probability Models II comparados con las predicciones de mortalidad hospitalaria de APACHE II y SAPS II. Medicina Intensiva 2000; 24:375-376

30. Sierra B, Serrano N, Larrañaga P, Plasencia EJ, Inza I, Jiménez JJ, Revuelta P, Mora ML. Using Bayesian networks in the construction of a bi-level multi-classifier. A case study using Intensive Care Unit patients data. Artif Intell Med 2001; 22:233-24

32. Serrano N, Gunning K. Interés y aplicación de los scores pronósticos en UCI. En: Montejo JC, García de Lorenzo A, Ortíz Leyva C, Bonet A, eds: Manual de Medicina Intensiva, 2ª edición. ISBN 84-8174-484-0. Ediciones Harcourt 2001, Madrid.